業績

2019年

Increase in phospholamban content in mouse skeletal muscle after denervation.
Komatsu M, Nakada T, Kawagishi H, Kato H, Yamada M.
Journal of Muscle Research and Cell Motility. in press

Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice.
Yamada Y, Harada M, Hashimoto K, Guo R, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y.
Glycoconjugate Journal 36(1):1-11

Prostanoid EP4 receptor-mediated augmentation of Ih currents in Aβ dorsal root ganglion neurons underlies neuropathic pain.
Zhang H, Kashihara T, Nakada T, Tanaka S, Ishida K, Fuseya S, Kawagishi H, Kiyosawa K, Kawamata M, Yamada M. 
J. Pharmacol. Exp. Ther. 368:50-58

2018年

Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism.
Guo R, Hu X, Yamada Y, Harada M, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y. 
Hypertension Research in press

Sonic hedgehog signaling regulates the mammalian cardiac regenerative response.
Kawagishi H, Xiong J, Rovira II, Pan H, Yan Y, Fleischmann BJ, Yamada M, Finkel T. 
J. Mol. Cell. Cardiol. 123:180-184

PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus.
Guo X, Kashihara T, Nakada T, Aoyama T, Yamada M.
Pflugers Arch. 470(6):909-921

Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction.
Nakada T, Kashihara T, Komatsu M, Kojima K, Takeshita T, Yamada M.
Proc. Natl. Acad. Sci. USA. 115: 4507-4512

2017年

Angiotensin II activates CaV 1.2 Ca2+ channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M.
J. Physiol. 595: 4207-4225

2015年

Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model.
Gautam M, Fujita D, Kimura K, Ichikawa H, Izawa A, Hirose M, Kashihara T, Yamada M, Takahashi M, Ikeda U, Shiba Y.
J. Mol. Cell. Cardiol. 81: 139-149

2014年

Molecular mechanism of junctional membrane-targeting of cardiac and skeletal muscle L-type calcium channels.
Nakada T, Yamada M.
Nihon Yakurigaku Zasshi. 144: 217-221

Cardiac overexpression of constitutively active Gαq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice.
Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M.
PLoS One. 29: e106354

Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts.
Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M.
Biol. and Pharm. Bull. 37: 1168-1176

β2-Adrenergic and M2-muscarinic receptors decrease basal t-tubular L-type Ca2+channel activity and suppress ventricular contractility in heart failure.
Kashihara T, Hirose M, Shimojo H, Nakada T, Gomi S, Hongoe M, Yamada M.
Eur. J. Pharmacol. 724: 122-131

TRPM4 channels mediate hypertonicity-induced, Ca2+-impermeable, Non-selective cation currents in a cervical cancer cell line, HeLa cells.
Gomi S, Nakada T, Kashihara T, Ikeda U, Yamada M.
Shinshu. Med. J. 62: 33-44

2013年

Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T.
Hypertension 61: 341-351

2012年

Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.
Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Yamada M. 
PLoS One 7: e52667

Proximal C-terminus of α1C subunits is necessary for junctional membrane-targeting of cardiac L-type calcium channels.
Nakada T, Flucher BE, Kashihara T, Sheng X, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Yamada M.
Biochem. J. 448: 221-231

KGA-2727, a Novel Selective Inhibitor of a High-Affinity Sodium Glucose Cotransporter (SGLT1), Exhibits Antidiabetic Efficacy in Rodent Models.
Shibazaki T, Tomae M, Ishikawa-Takemura Y, Fushimi N, Itoh F, Yamada M, Isaji M.
J. Pharmacol. Exp. Ther. 342: 288-296

Two Mechanistically Distinct Effects of Dihydropyridine Nifedipine on CaV1.2 L-Type Ca2+ Channels Revealed by Timothy Syndrome Mutation.
Sheng X, Nakada T, Kobayashi M, Kashihara T, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Aoyama T, Yamada M.
Eur. J. Pharmacol. 685: 15-23

Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure.
Kashihara T, Nakada T, Shimojo H, Horiuchi-Hirose M, Gomi S, Shibazaki T, Sheng X, Hirose M, Hongo M, Yamada M.
Am. J. Physiol. Heart Circ. Physiol. 302: H1645-H1654

2011年

Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure.
Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M.
Circ. J. 75: 2333-2342

Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes.
Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M.
Am. J. Physiol. Heart Circ. Physiol. 300: H978-H988

Acid-Sensing Ion Channels in Blood Volume Regulation.
Yamada M.
Circ. J. 75: 781-782

Thrombin activates Ca2+-permeating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells.
Tsujino N, Nakada T, Tsubouchi K, Kobayashi M, Kawai Y, Yano S, Matsunaga T, Hirose M, Ohmori S, Ohhashi T, Yamada M. 
Shinshu Med. J. 59: 13-26

Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M.
Int. J. Cardiol. 146: 37-43

2010年

Selective α1A-Adrenoceptor Stimulation Induces Mueller’s Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation.
Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M.
Curr. Eye Res. 35: 363-369

Mitochondrial ATP-sensitive K+ channels, protectors of the heart.
Yamada M.
J. Physiol. (Lond.) 582: 283-286

2009年

Effects of hormone-sensitive lipase-disruption on cardiac energy metabolism in response to fasting and refeeding.
Suzuki J, Ueno M, Uno M, Hirose Y, Zenimaru Y, Takahashi S, Osuga JI, Ishibashi S, Takahashi M, Hirose M, Yamada M, Kraemer FB, Miyamori I.
Am. J. Physiol. Endocrinol. Metab. 297: E1115-E1124

Diacylglycerol kinase zeta inhibits Gαq-induced atrial remodeling in transgenic mice. 
Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M.

Heart Rhythm. 6: 78-84